| ncRNA name | PTX3 siRNA |
| ncRNA Category | siRNA |
| Disease name | fungal keratitis |
| Species | Homo sapiens |
| Tissues/Cell_line | human corneal epithelial cell (HCECs) |
| Methods | siRNA transfection, immunochemistry, qRT-PCR, Western blot, ELISA |
| Expression pattern | associated |
| Functional description | PTX3 plays a proinflammatory role in corneal epithelial anti-fungi immune response by affecting the production of IL-1β and activation of some proinflammatory signaling pathways (ERK1/2 and JNK). Blocking of endogenous PTX3 by siRNA down-regulated the production of IL-1β at both mRNA and protein levels. |
| PubMed ID | 27889356 |
| Year | 2018 |
| Title | Role of PTX3 in corneal epithelial innate immunity against Aspergillus fumigatus infection. |
| Drug-related ncRNA | NO |
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